Stephens CA, Marcoline FV, Peters CJ, Grabe M. Conformational changes upon pore blocker removal reveal conductive states of TMEM16A. bioRxiv [Preprint]. 2026 Jan 3:2026.01.02.697443. doi: 10.64898/2026.01.02.697443. PMID: 41509275
Miguelez Fernández AMM, Netherton S, Niladhuri SB, Brown AC, Rivera P, Tseng KY, Peters CJ. Chemogenetic control of GABAergic neurons within the interpeduncular nucleus reveals dissociable behavioral components of the nicotine withdrawal phenotype. Neurobiol Dis. 2026 Jan;218:107240. doi: 10.1016/j.nbd.2025.107240. Epub 2025 Dec 22. PMID: 41443382
Zurawski Z, Lu I, Potcoava M, Delbove CE, Peters CJ, Hamm H, Alford S. Presynaptic GABAB autoreceptors suppress neurotransmitter release during repetitive stimulation via the Gβγ-SNARE pathway. bioRxiv [Preprint]. 2025 Dec 10.693514; doi: https://doi.org/10.64898/2025.12.10.693514
Kulkarni GC, Saha R, Peters CJ. Ion channel expression and function in glioblastoma multiforme (GBM): pathophysiological mechanisms and therapeutic potential. Biochim Biophys Acta Mol Cell Res. 2025 Aug;1872(6):119982. doi: 10.1016/j.bbamcr.2025.119982. Epub 2025 May 5. PMID: 40328081
Kremiller KM, Kulkarni GC, Harris LM, Gunasekara H, Kashyap Y, Ilktach G, Nguyen A, Ondrus AE, Hu YS, Wang ZJ, Riley AP, Peters CJ. Discovery of Antinociceptive α9α10 Nicotinic Acetylcholine Receptor Antagonists by Stable Receptor Expression. ACS Chem Biol. 2024 Nov 15;19(11):2291-2303. doi: 10.1021/acschembio.4c00330. Epub 2024 Oct 13. PMID: 39396195
Rusali LE, Lopez-Hernandez AM, Kremiller KM, Kulkarni GC, Gour A, Straub CJ, Argade MD, Peters CJ, Sharma A, Toll L, Cippitelli A, Riley AP. Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior. J Med Chem. 2024 Jan 11;67(1):529-542. doi: 10.1021/acs.jmedchem.3c01758. Epub 2023 Dec 27. PMID: 38151460
Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 Mar 7;97(5):1063-1077.e4. doi: 10.1016/j.neuron.2018.01.048. Epub 2018 Feb 22. PubMed PMID: 29478917; PubMed Central PMCID: PMC5860880.
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 Dec 21;552(7685):426-429. doi: 10.1038/nature25024. Epub 2017 Dec 13. PubMed PMID: 29236684; PubMed Central PMCID: PMC5750132.
Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY. Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3547-52. doi: 10.1073/pnas.1502291112. Epub 2015 Mar 2. PubMed PMID: 25733897; PubMed Central PMCID: PMC4371966.
Tien J*, Peters CJ*, Wong XM, Cheng T, Jan YN, Jan LY, Yang H. A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife. 2014 Jun 30;3. doi: 10.7554/eLife.02772. PubMed PMID: 24980701; PubMed Central PMCID: PMC4112547. (* denotes equal contribution)
Peters CJ, Fedida D, Accili EA. Allosteric coupling of the inner activation gate to the outer pore of a potassium channel. Sci Rep. 2013 Oct 23;3:3025. doi: 10.1038/srep03025. PubMed PMID: 24149575; PubMed Central PMCID: PMC3806241.
Peters CJ, Werry D, Gill HS, Accili EA, Fedida D. Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore. J Neurosci. 2011 Nov 30;31(48):17449-59. doi: 10.1523/JNEUROSCI.2940-11.2011. PubMed PMID: 22131406.
Click here for a full list of Dr. Peters' publications at NCBI